Potential SARS-CoV-2 First-Aid
Need for research to determine if raw garlic is viable to serve as a First-Aid to defend from the SARS-CoV-2 Virus
Though organosulfur compounds found in raw garlic have been found to _not_ pose antimicrobial*1 defense against the SARS-CoV-2 virus, its ability to restore respiratory function after pulmonary fibrosis and ischemia-reperfusion injury in the lungs is promising.
A literature survey (assisted by an online search for 'covid-19 chest images' AND 'bronchial distortion' OR 'honeycombing' OR 'linear opacities with crazy-paving pattern') that analyze CT scan images of people diagnosed with SARS-CoV-2, the opacities (bronchial distortion; honeycombing; and linear opacities with crazy-paving pattern) are similar to those with pulmonary fibrosis. Thus prompting the notion that organosulfur compounds in raw garlic may be able to recover from loss in respiratory function (pulmonary fibrosis*2 and ischemia-reperfusion injury in the lungs*3) caused by the SARS-CoV-2 virus.
"Researchers at MIT and the University of Colorado at Denver have proposed a stopgap measure that they believe could help SARS-CoV-2 patients who are in acute respiratory distress. By repurposing a drug that is now used to treat blood clots, they believe they could help people in cases where a ventilator is not helping, or if a ventilator is not available"*4. This hypothesis proposes the merit of organosulfur compounds found in raw garlic that are known to provide anti-fibrotic relief as a likely method to relieve acute oxygen insufficiency experienced by people affected by the coronavirus and hence serve as first-aid to obviate uncertainty under present circumstances.
In addition to providing anti-fibrotic relief, the organosulfur compounds in raw garlic are also found to provide anticoagulant*5,*6, antimicrobial (i.e. offset secondary infection), antiinflammatory and immune response*7.
To ascertain the efficacy of administering raw garlic to patients affected by the SARS-CoV-2 virus, immune response to acute infection scenarios*8 affecting the lungs is reviewed:
This hypothesis suggesting high intake of raw garlic provide expeditious and substantive relief is supported by its effect on relieving injury to heart*18 and kidney*19.
In summary, the organosulfur compounds found in raw garlic even if not effective in directly neutralizing the SARS-CoV-2 virus, its anti-fibrotic, antiinflammatory, anticoagulant and immunomodulatory functions reduce the risk of acute oxygen insufficiency, chances of concomitant secondary infection (antimicrobial effect on microbes other than SARS-CoV-2) and hence estimated to serve as an accessible and affordable first-aid to save lives and obviate the prevailing uncertainty.
NOTE: Please consult a medical professional to make sure if consuming raw garlic is right for you. On a personal note, I have overcome instances of breathing problems associated with lung fibrosis since 2018 October (a point in time where I experimented with raw garlic) by ingesting a liquefied mixture of raw garlic (about 15-20 grams) and tomato (of quantity to dampen the acrid taste of raw garlic and possibly beneficial antioxidant quality of lycopene found in raw tomato) to provide noticeable improvement in about half hour after intake of raw garlic preparation. In support of the notion that high intake of raw garlic should be limited to at most 2-3 days (based on personal experiences), prolonged intake of raw garlic is known to induce hemolytic anemia*20. To maximize the assimilation of raw garlic, I have found the benefit of ingesting/infusing Vitamin B12 and Alpha Lipoic Acid.
*1 Potential Inhibitor of COVID-19 Main Protease (Mpro) From Several Medicinal Plant Compounds by Molecular Docking Study. https://www.preprints.org/manuscript/202003.0226/v1.
*2 Attenuation of Bleomycin-Induced Pulmonary Fibrosis in Rats with S-Allyl Cysteine. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154609.
*3 Intravenous allicin improves pulmonary blood flow after ischemia-reperfusion injury in rats. https://www.ncbi.nlm.nih.gov/pubmed/11887050.
*4 COVID-19: Stopgap measure to treat respiratory distress. https://www.sciencedaily.com/releases/2020/03/200325120845.htm.
*5 Identifying the Anti-Blood-Clotting Compounds in Garlic. https://clinicaltrials.gov/ct2/show/results/NCT00200785#all
*6 16 SECRET DISEASE FIGHTERS. http://www.uky.edu/~garose/bio425-cancer01.htm. Context, in this presentation, Dr. Larry Dawson's findings on garlic are described.
*7 Immunomodulation and anti-inflammatory effects of garlic compounds. http://doi.rg/10.1155/2015/401630.
*8 Into the Eye of the Cytokine Storm. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3294426.
*9 Associations between immune-suppressive and stimulating drugs and novel COVID-19â€”a systematic review of current evidence. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105343.
*10 A novel natural compound from garlic (Allium sativum L.) with therapeutic effects against experimental polymicrobial sepsis. https://doi.org/10.1016/j.bbrc.2015.07.031.
*11 Allicin inhibits spontaneous and TNF-alpha induced secretion of proinflammatory cytokines and chemokines from intestinal epithelial cells. https://www.doi.org/10.1016/j.clnu.2004.03.011.
*12 Phytochemicals against TNFÎ±-Mediated Neuroinflammatory Diseases. https://www.mdpi.com/1422-0067/21/3/764/htm.
*13 Trials of anti-tumour necrosis factor therapy for COVID-19 are urgently needed. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30858-8/fulltext
*14 COVID-19: risk for cytokine targeting in chronic inflammatory diseases?. https://doi.org/10.1038/s41577-020-0312-7. Context, please refer to Fig. 1.
*15 A Single Meal Containing Raw, Crushed Garlic Influences Expression of Immunity- and Cancer-Related Genes in Whole Blood of Humans. https://doi.org/10.3945/jn.115.215392.
*16 Regulatory T cells and anti-inflammatory cytokine profile of mice fed a high-fat diet after single-bulb garlic (Allium sativum L.) oil treatment. http://dx.doi.org/10.4314/tjpr.v17i11.7.
*17 Garlic and Organosulfur Compounds. https://lpi.oregonstate.edu/mic/food-beverages/garlic. Accessed on 24 April 2020.
*18 Effect of garlic on cardiovascular disorders: a review. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139960. Context, high/acute intake provide rapid improvement, fibrinolytic agent.
*19 Histopathological Assessment of the Kidney of Alloxan Induced Diabetic Rat Treated with Macerated Allium Sativum (garlic). http://www.doi.org/10.15272/ajbps.v4i35.214. Context, high intake restores kidney damage.
*20 Prevention of garlic-induced hemolytic anemia using some tropical green leafy vegetables. http://www.doi.org/10.1089/jmf.2004.7.498. Context, need to mix raw garlic with another raw vegetable.